Serious and sometimes fatal adverse reactions occurred with LUNSUMIO treatment. Warnings and precautions include cytokine release syndrome, neurologic toxicity, infections, cytopenias, tumor flare, and embryo-fetal toxicity.
*From the initial occurrence of the documented PR or CR.1
LUNSUMIO was studied across patient subgroups, including: age, refractory status, prior treatment, bulky disease, and FLIPI risk factors.
Limitations: These post hoc analyses were exploratory and no formal inference may be drawn.
Prior treatment type | ||
---|---|---|
Demographic | ORR | CR |
FLIPI ≥3 (n=40) | 83% | 60% |
Bulky disease (n=31) | 74% | 61% |
Refractory to last prior therapy (n=62) | 77% | 52% |
Refractory to any prior anti-CD20 therapy (n=71) | 77% | 55% |
Refractory to any prior anti-CD20 therapy and an alkylating agent (double refractory) (n=48) |
71% | 50% |
Refractory to any prior PI3K inhibitor (n=12) |
75% | 50% |
Prior rituximab-lenalidomide therapy (n=8) | 75% | 25% |
Prior CAR T-cell therapy (n=3) | 100% | 33% |
POD24 (n=47) | 85% | 57% |
EZH2 mutation (n=8) | 75% | 38% |
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3L+=third-line or later; auto-SCT=autologous stem cell transplant; CAR=chimeric antigen receptor; CI=confidence interval; CR=complete response; DOR=duration of response; DORC=duration of response in patients who achieved CR; FL=follicular lymphoma; FLIPI=Follicular Lymphoma International Prognostic Index; IRF=independent review facility; NE=not estimable; ORR=objective response rate; Pts=patients.
LUNSUMIO. Prescribing Information. Genentech, Inc.
LUNSUMIO. Prescribing Information. Genentech, Inc.
FDA grants Breakthrough Therapy Designation for Roche’s CD20xCD3 bispecific cancer immunotherapy lunsumioetuzumab recognising its potential in follicular lymphoma. News release. July 14, 2020. Accessed December 17, 2021. https://www.roche.com/investors/updates/inv-update-2020-07-14b.htm.
FDA grants Breakthrough Therapy Designation for Roche’s CD20xCD3 bispecific cancer immunotherapy lunsumioetuzumab recognising its potential in follicular lymphoma. News release. July 14, 2020. Accessed December 17, 2021. https://www.roche.com/investors/updates/inv-update-2020-07-14b.htm.
Budde LE, Sehn LH, Matasar M, et al. Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study. Lancet Oncol. Published online July 5, 2022. doi:10.1016/S1470-2045(22)00335-7.
Budde LE, Sehn LH, Matasar M, et al. Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study. Lancet Oncol. Published online July 5, 2022. doi:10.1016/S1470-2045(22)00335-7.
Data on file. Genentech, Inc; 2022.
Data on file. Genentech, Inc; 2022.
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